Alzheimer’s disease (AD) is a neurodegenerative disease leading to progressive loss of memory and thinking skills. AD is the most common form of dementia. Early Alzheimer’s disease, which includes Mild cognitive impairment due to AD and Mild AD.
Mild cognitive impairment due to Alzheimer's disease or mild Alzheimer’s dementia is consistent with Stages 3-4, as defined by the AD diagnostic guidelines of the National Institute of Aging-Alzheimer’s Association.
With time, Alzheimer’s disease gets worse and progresses over the course of many years. AD causes mild cognitive impairment, memory loss, and may impact functional abilities in its early stages.
Although an AD diagnosis is confirmed through the presence of amyloid plaques and neurofibrillary tangles in the brain, other factors are known to be involved in AD processes. These include oxidative stress, mitochondrial dysfunction, hormone dysregulation, inflammation, calcium imbalance, and genetic risk factors. AD is now recognized as involving multifactorial causes and processes.
Given the multifactorial nature of AD, its high prevalence and financial burden, and the devastating disease course, there is a high demand for more effective treatments.
Early symptoms of Alzheimer’s are: